Observational trials are research studies that involve observing and monitoring participants in their natural environment or real-life settings, without intervening or manipulating any variables. These trials aim to collect data on various factors, behaviors, or outcomes to better understand the natural progression of a disease or condition, the effectiveness of a particular treatment, or the impact of certain lifestyle factors. Observational trials can provide valuable insights into the associations between different variables, help identify potential risk factors or protective factors, and inform future clinical research. They are often used when conducting randomized controlled trials may be unethical or not feasible. Overall, observational trials play an important role in generating hypotheses, exploring relationships between variables, and informing evidence-based decision-making in healthcare.